The purpose of the PANOPTIS project is to improve the resiliency (ability to adapt) of the road infrastructures and ensuring reliable network availability under unfavourable conditions, such as extreme weather, landslides, and earthquakes. The project’s main goal is to combine down-scale climate change scenarios (applied to road infrastructure) with structural and geotechnical simulation tools, and with actual data from sensors (terrestrial and airborne) so as to provide the operators with an integrated tool able to support more effective management of their infrastructures at planning, maintenance and operation level.